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Antabuse (Antibuse) works by blocking the breakdown of alcohol, causing unpleasant side effects (eg, vomiting, upset stomach) when even a small amount of alcohol is consumed. Inform patient that alcohol may react with tolbutamide and cause Antabuse -like reaction (eg, flushing, headache, dizziness, high BP). Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Antabuse. It is unknown if Antabuse is excreted in breast milk. Using Antabuse alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
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